![]() You even see differing receptor-activation between a single class of psychedelics. It’s true that LSD and tryptamine activate receptors that are not activated by phenethylamines, and vice versa, but these play a secondary role to the primary effects of psychedelics. Receptor-activation is key here.Īccording to Psychopharmacology – Drugs, the brain and behavior (Meyer and Quenzer, 2005), LSD as well as phenethylamines activate the 5-HT2A and 2C sub-type receptors, which are thought to modulate the subjective and behaviorial effects of most, if not all, psychedelics. With cross-tolerance, one should think in terms of mechanism of action (pharmacodynamics) rather than chemical structure. Listen to our regular podcast to hear insights about microdosing from entrepreneurs, psychedelic experts and self-medicators.Īlso, join our mailing list and sign up for our microdosing course to gain exclusive benefits! Join our forum to talk to other microdosers about your experience, and gain useful insight from our other community members. We recommend avoiding long periods of microdosing (more than a few months), as the long-term health effects are unknown at this time. Keep a journal to note how the microdosing is changing your mood or perceptions.Īfter a few weeks, stop your regimen and take a break to reflect on how things have changed, and what you might want to do differently if you decide to microdose again. That is, you’ll dose on day 1, take days 2 and 3 off, then dose again on day 4 (and so on).Ĭontinue this schedule for several weeks, and you should start to notice effects. ![]() The recommended starting routine for microdosing is to dose once every three days. Once you’ve found the right dose for you, it’s time to make a schedule. If you’re microdosing to reduce anxiety, you might want to observe how easy social interactions are.įor more details on how to observe the effects of microdosing, relevant to your intention, sign up for our online microdosing course. If you’re microdosing for improved productivity, you might want to look out for feelings of increased focus and less procrastination. If you feel like things get a little too intense, try reducing the dose next time.ĭepending on why you want to microdose, you might be looking for different effects. If you feel like you didn’t reach the desired state, take a couple of days off then microdose again with a slightly higher amount. You’ll want to take your first ever dose on a day off, and not plan any intense activities, so you can relax and monitor what the microdose does to your mind and body. ![]() Read our full guide on how to measure out a microdose of psilocybin mushrooms here. If you’re microdosing with psilocybin mushrooms, you’ll want to start out with a dose of around 0.2 grams. To measure this out, you can either cut up your tab into smaller pieces (inaccurate but quick) or dissolve a tab in distilled water (known as volumetric microdosing – read our full guide). If you’re microdosing with LSD, you’ll want to start out with a small dose of around 5ug. Here is an in-depth guide into the legal status of microdosing. Fostering a community will always help people find what they’re looking for! The best advice, however, is to get involved with your local psychedelic society, and start making friends. However, we can provide you information on the nuances of the law in different countries, and let you know about totally legal ways of getting your hands on psychedelics – such as growing your own psilocybin mushrooms (in certain countries) or purchasing legal versions of prohibited substances. Since most psychedelics are currently illegal, we can’t give you advice on how to obtain certain substances. No matter where your interest in microdosing has come from, the first question is always: Maybe you’ve heard about the many benefits that microdosing is reported to provide? Maybe you’ve read an article on microdosing, or heard a popular podcast on the topic. So you’re interested in starting microdosing?
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